This House is Falling Apart

I have known intimately and looked after depressed people, and have no illusions about my ability to understand the real nature of that illness. The sort of blues I occasionally suffer through compares to real depression like a broken fingernail compares to being shot in the head and then set on fire and drowned. But it seems to me that the victims of that terrible disorder are often trying all their lives in vain to figure out why this must be so. Why them. And maybe there really is just no reason, or the reason is completely random, a cluster of neurons misfiring one day by accident, a bad thing that happens and could not be helped.
-Inside David Foster Wallace's Private Self-Help Library-